New Madrid County Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your New Madrid County Vacation
With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.
New Madrid County Hotel Deals
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
CA $135
CA $153 total
Aug 23 - Aug 24
includes taxes & fees
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
CA $136
CA $154 total
Aug 23 - Aug 24
includes taxes & fees
9/10 Wonderful! (607 reviews)
"Hotel was nice but unfortunately someone decided to smoke in the elevator one night which made it shut down. So, until the repair was completed, everyone one the upper floors had to take the stairs down multiple floors. Usually not that big of an issue, but we were there for a bike ride and had to ..."
Reviewed on Aug 10, 2026
Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
CA $141
CA $159 total
Aug 23 - Aug 24
includes taxes & fees
9.4/10 Exceptional! (103 reviews)
"Staff were excellent! Very personable with us!"
Reviewed on Aug 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a New Madrid County vacation package cost?
Customize your New Madrid County package from a low . Choose from any combination of hotels, flights and rental cars to pull together the getaway you've long been dreaming about. Remember to add on a few experiences or activities!
How do I get a cheap travel package to New Madrid County?
Bundling your hotel and flight with Expedia won't just save you time — it'll save you a pretty penny too. A New Madrid County vacation package makes it easy to put together your dream adventure. With more than 550 airlines across the world to choose from, finding convenient flights that fit your schedule won't be a hassle. Not only that, we've got over 1,000,000 properties globally to pick from. Now that's what we call choice. No matter who you are, Expedia puts more of the world within your reach.
What are the top hotels in New Madrid County?
Portageville is one place that most visitors to New Madrid County include in their itinerary. For a memorable stay here, check out Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel.
How far in advance should I book my New Madrid County vacation?
To bag cheap prices, book nice and early. Air carriers usually advertise flights, along with some of the lowest fares, up to 12 months prior to departure. Hotels, activities and car rental should also be booked early so you can have the pick of the bunch. If you've decided on a last-minute getaway in New Madrid County, there are always plenty of great bargains to be had on Expedia. Book your escape today!
What does an Expedia New Madrid County travel package include?
Packages include hotels, rental cars and flights, but you can combine any of them to create your dream New Madrid County escape. You can also add on fun stuff like activities and tours once you've made your booking. You're in charge! When you bundle your bookings with Expedia, you'll score discounts you won't find elsewhere.
What should I know before booking a New Madrid County travel package?
You'll score great savings when you bundle your hotels, flights and rental cars into a package. Plus, booking everything in one spot makes trip planning easier. So why waste time or money? Whether you're organizing a luxury romantic escape or a budget solo adventure, take a look at our vacation packages today.
Can I choose my airline with a New Madrid County Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines around the world. Our vacation packages give you the flexibility to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my New Madrid County vacation package?
You sure can, and we're here to help. You may be able to change or cancel your New Madrid County vacation package for free within 24 hours of booking. But you may be charged a fee by your airline, hotel or car rental company for older bookings. If your circumstances suddenly change, visit our Customer Service Portal for further information.
Stay near popular New Madrid County attractions
New Madrid Historical Museum
8.2/10 (36 reviews)
You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.
Hunter-Dawson State Historic Site
7.6/10 (13 reviews)
You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.
River Ridge Winery
8.4/10 (15 reviews)
You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.
Marston Community Center
Marston Community Center is just one of the places to see in Marston, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its museums.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
