New Madrid County Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place

Your New Madrid County Vacation

With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.

New Madrid County Hotel Deals

Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $139 per night from May 31 to Jun 1
CA $139
CA $158 total
May 31 - Jun 1
includes taxes & fees
9/10 Wonderful! (560 reviews)
Everything was good

Reviewed on May 10, 2026

Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $151 per night from May 31 to Jun 1
CA $151
CA $171 total
May 31 - Jun 1
includes taxes & fees
9.4/10 Exceptional! (77 reviews)
Everything was spectacular

Reviewed on May 11, 2026

Fairfield Inn & Suites by Marriott Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Fully refundable
The price is CA $144 per night from Jun 7 to Jun 8
CA $144
CA $163 total
Jun 7 - Jun 8
includes taxes & fees
8.6/10 Excellent! (462 reviews)
The staff was friendly and helpful even when arriving late in the evening. Room was clean and bed was very comfortable.

Reviewed on May 1, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
See all 99 properties in New Madrid County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
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Frequently asked questions

How much does a New Madrid County vacation package cost?
Customize your New Madrid County package from a low . Choose from any combination of hotels, flights and rental cars to pull together the getaway you've long been dreaming about. Remember to add on a few experiences or activities!
How do I get a cheap travel package to New Madrid County?
Bundling your hotel and flight with Expedia won't just save you time — it'll save you a pretty penny too. A New Madrid County vacation package makes it easy to put together your dream adventure. With more than 550 airlines across the world to choose from, finding convenient flights that fit your schedule won't be a hassle. Not only that, we've got over 1,000,000 properties globally to pick from. Now that's what we call choice. No matter who you are, Expedia puts more of the world within your reach.
What are the top hotels in New Madrid County?
Portageville is one place that most visitors to New Madrid County include in their itinerary. For a memorable stay here, check out Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel.
How far in advance should I book my New Madrid County vacation?
To bag cheap prices, book nice and early. Air carriers usually advertise flights, along with some of the lowest fares, up to 12 months prior to departure. Hotels, activities and car rental should also be booked early so you can have the pick of the bunch. If you've decided on a last-minute getaway in New Madrid County, there are always plenty of great bargains to be had on Expedia. Book your escape today!
What does an Expedia New Madrid County travel package include?
Packages include hotels, rental cars and flights, but you can combine any of them to create your dream New Madrid County escape. You can also add on fun stuff like activities and tours once you've made your booking. You're in charge! When you bundle your bookings with Expedia, you'll score discounts you won't find elsewhere.
What should I know before booking a New Madrid County travel package?
You'll score great savings when you bundle your hotels, flights and rental cars into a package. Plus, booking everything in one spot makes trip planning easier. So why waste time or money? Whether you're organizing a luxury romantic escape or a budget solo adventure, take a look at our vacation packages today.
Can I choose my airline with a New Madrid County Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines around the world. Our vacation packages give you the flexibility to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my New Madrid County vacation package?
You sure can, and we're here to help. You may be able to change or cancel your New Madrid County vacation package for free within 24 hours of booking. But you may be charged a fee by your airline, hotel or car rental company for older bookings. If your circumstances suddenly change, visit our Customer Service Portal for further information.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.